GHK-Cu is the copper complex of glycyl-L-histidyl-L-lysine — one of the most extensively documented signalling peptides in dermal research.
GHK-Cu is the 1:1 complex of the tripeptide GHK (Gly-His-Lys) with divalent copper. The complex coordinates Cu²⁺ through the imidazole nitrogen of histidine, the α-amino group of glycine and a deprotonated peptide nitrogen, forming the signalling-active species with a characteristic deep-blue colour.
Documented research signalling
- Modulates extracellular-matrix gene expression in cultured fibroblasts.
- Influences SOD and antioxidant enzyme expression in in-vitro models.
- Demonstrates collagen and decorin binding site affinity in laboratory studies.
- Supports angiogenic-marker expression in cell-culture wound-model literature.
COA verification
- ≥98% HPLC purity of the GHK peptide.
- Quantified copper content (~17–20% by mass for the 1:1 complex).
- LC-MS confirmation of GHK mass (340.4 Da).
- UV-Vis absorbance at ~620 nm consistent with the Cu²⁺ complex.
Research use only. All information on this page is provided strictly for in-vitro and laboratory research reference. Nothing in this article is medical, therapeutic, dosing, or performance advice for human or veterinary use.
