FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the FOXO4–p53 interaction in senescent cell research.
FOXO4-DRI is a D-retro-inverso (DRI) analog of a FOXO4 fragment designed to competitively disrupt the FOXO4–p53 interaction, which is upregulated in senescent cells. Published in-vitro research characterises it as a proof-of-concept senolytic reference peptide.
- D-retro-inverso backbone for proteolytic resistance.
- Competitive disruption of the FOXO4–p53 interaction.
- Frequently referenced in cellular-senescence research.
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
Research use only. All information on this page is provided strictly for in-vitro and laboratory research reference. Nothing in this article is medical, therapeutic, dosing, or performance advice for human or veterinary use.
