GHRP-2 and GHRP-6 are both GHSR (ghrelin) receptor agonists. Here is exactly how their published selectivity and side-effect profiles diverge.
| Attribute | GHRP-2 | GHRP-6 |
|---|---|---|
| Class | Hexapeptide GHSR agonist | Hexapeptide GHSR agonist |
| GH release potency | Higher published magnitude | Moderate |
| Appetite induction | Modest | Marked (published in rodent literature) |
| ACTH/cortisol induction | Modest | Modest |
| Research use case | GH-axis PK reference | Appetite-model reference |
Both compounds have been superseded in modern selective-secretagogue research by ipamorelin, which lacks the prolactin and cortisol confounds. GHRP-2 and GHRP-6 remain historical reference compounds.
Research use only. All information on this page is provided strictly for in-vitro and laboratory research reference. Nothing in this article is medical, therapeutic, dosing, or performance advice for human or veterinary use.
